Developmental Signals - Nerve Growth Factor
Embryology - 9 May 2024 Expand to Translate |
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Introduction
Nerve Growth Factor (NGF) was first discovered in the 1950's by Rita Levi-Montalcini with Stanley Cohen and Viktor Hamburger.[1][2] See review Levi-Montalcini review 30 years later.[3]
For which Rita Levi-Montalcini and Stanley Cohen received the 1986 Nobel Prize in Medicine.[4]
The Nobel Prize in Physiology or Medicine 1986 - Stanley Cohen, Rita Levi-Montalcini "for their discoveries of growth factors"
Draft page - Notice removed when completed.
Historical: Cohen S. Levi-Montalcini R. and Hamburger V. A nerve growth-stimulating factor isolated from sarcomas 37 and 180. (1954) Proc Natl Acad Sci U S A. 40(10):1014-8. PMID: 16589582
Note - NGF is also used as an acronym in ovary development for a Non-Growing Follicle.
Factor Links: AMH | hCG | BMP | sonic hedgehog | bHLH | HOX | FGF | FOX | Hippo | LIM | Nanog | NGF | Nodal | Notch | PAX | retinoic acid | SIX | Slit2/Robo1 | SOX | TBX | TGF-beta | VEGF | WNT | Category:Molecular |
Some Recent Findings
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More recent papers |
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This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
More? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Nerve Growth Factor |
Older papers |
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These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
See also the Discussion Page for other references listed by year and References on this current page. |
Structure
Gene
Protein
Function
Neural
- Links: Neural System Development
Signaling Pathway
Receptor
Tyrosine Kinase Receptor A
TRKA
NTKR1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors.
- OMIM Links: TRKA
Nerve Growth Factor Receptor
NGFR; p75(NTR)
Receptor binds at low affinity NGF and other neurotrophins: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4).
Intracellular Signaling
Other Neural Growth Factors
- Brain-derived neurotrophic factor (BDNF)
- Glial cell line-derived neurotrophic factor (GDNF)
- Neurotrophic 3 (NT3)
Abnormalities
Neurotrophic Keratitis
A degenerative disease of the eye characterized by decreased corneal sensitivity and poor corneal healing. This is not directly related to NGF, other than the recent application of NGF in clinical trials for treatment of this disorder.[8]
OMIM
About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM
References
- ↑ LEVI-MONTALCINI R & HAMBURGER V. (1951). Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J. Exp. Zool. , 116, 321-61. PMID: 14824426
- ↑ Cohen S. Levi-Montalcini R. and Hamburger V. A nerve growth-stimulating factor isolated from sarcomas 37 and 180. (1954) Proc Natl Acad Sci U S A. 40(10):1014-8. PMID: 16589582
- ↑ Levi-Montalcini R. (1987). The nerve growth factor: thirty-five years later. EMBO J. , 6, 1145-54. PMID: 3301324
- ↑ Melino G, Benedetti B & Bazan N. (2013). On Rita Levi-Montalcini. Mol. Neurobiol. , 47, 443-5. PMID: 23389287 DOI.
- ↑ Nittoli V, Sepe RM, Coppola U, D'Agostino Y, De Felice E, Palladino A, Vassalli QA, Locascio A, Ristoratore F, Spagnuolo A, D'Aniello S & Sordino P. (2018). A comprehensive analysis of neurotrophins and neurotrophin tyrosine kinase receptors expression during development of zebrafish. J. Comp. Neurol. , 526, 1057-1072. PMID: 29322524 DOI.
- ↑ Sunagar K, Fry BG, Jackson TN, Casewell NR, Undheim EA, Vidal N, Ali SA, King GF, Vasudevan K, Vasconcelos V & Antunes A. (2013). Molecular evolution of vertebrate neurotrophins: co-option of the highly conserved nerve growth factor gene into the advanced snake venom arsenalf. PLoS ONE , 8, e81827. PMID: 24312363 DOI.
- ↑ Aloe L, Rocco ML, Bianchi P & Manni L. (2012). Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med , 10, 239. PMID: 23190582 DOI.
- ↑ Bonini S, Lambiase A, Rama P, Sinigaglia F, Allegretti M, Chao W & Mantelli F. (2018). Phase 2 Randomized, Double-Masked, Vehicle-Controlled Trial of Recombinant Human Nerve Growth Factor for Neurotrophic Keratitis. Ophthalmology , , . PMID: 29653858 DOI.
Reviews
Rocco ML, Soligo M, Manni L & Aloe L. (2018). Nerve Growth Factor: Early Studies And Recent Clinical Trials. Curr Neuropharmacol , , . PMID: 29651949 DOI.
Indo Y. (2018). NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. Neurosci Biobehav Rev , 87, 1-16. PMID: 29407522 DOI.
Rocco ML, Soligo M, Manni L & Aloe L. (2018). Nerve Growth Factor: Early Studies And Recent Clinical Trials. Curr Neuropharmacol , , . PMID: 29651949 DOI.
Barald KF, Shen YC & Bianchi LM. (2018). Chemokines and cytokines on the neuroimmunoaxis: Inner ear neurotrophic cytokines in development and disease. Prospects for repair?. Exp. Neurol. , 301, 92-99. PMID: 29080793 DOI.
Su YW, Zhou XF, Foster BK, Grills BL, Xu J & Xian CJ. (2018). Roles of neurotrophins in skeletal tissue formation and healing. J. Cell. Physiol. , 233, 2133-2145. PMID: 28370021 DOI.
Heumann R. (1987). Regulation of the synthesis of nerve growth factor. J. Exp. Biol. , 132, 133-50. PMID: 3323396
Misko TP, Radeke MJ & Shooter EM. (1987). Nerve growth factor in neuronal development and maintenance. J. Exp. Biol. , 132, 177-90. PMID: 2828509
Levi-Montalcini R. (1987). The nerve growth factor: thirty-five years later. EMBO J. , 6, 1145-54. PMID: 3301324
Articles
Ceci FM, Ferraguti G, Petrella C, Greco A, Tirassa P, Iannitelli A, Ralli M, Vitali M, Ceccanti M, Chaldakov GN, Versacci P & Marco F. (2020). Nerve Growth Factor, Stress and Diseases. Curr. Med. Chem. , , . PMID: 32811396 DOI.
All Rita Levi-Montalcini PMID references
Kuypers E, Collins JJ, Jellema RK, Wolfs TG, Kemp MW, Nitsos I, Pillow JJ, Polglase GR, Newnham JP, Germeraad WT, Kallapur SG, Jobe AH & Kramer BW. (2012). Ovine fetal thymus response to lipopolysaccharide-induced chorioamnionitis and antenatal corticosteroids. PLoS ONE , 7, e38257. PMID: 22693607 DOI.
Online Textbooks
- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al.New York: Garland Science; 2002.
- Molecular Cell Biology. 4th edition. Lodish H, Berk A, Zipursky SL, et al.New York: W. H. Freeman; 2000.
- Madame Curie Bioscience Database [Internet]. Austin (TX): Landes Bioscience; 2000.
Search PubMed
- Search PubMed: Nerve Growth Factor
- All Databases: Nerve Growth Factor
External Links
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- OMIM - NGF
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Cite this page: Hill, M.A. (2024, May 9) Embryology Developmental Signals - Nerve Growth Factor. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Developmental_Signals_-_Nerve_Growth_Factor
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G