Cardiovascular System Development
Development of the heart and vascular system begins very early in mesoderm both within (embryonic) and outside (extra embryonic, yolk sac and placental) the embryo. Vascular development therefore occurs in many places, the most obvious though is the early forming heart, which grows rapidly creating an externally obvious cardiac "bulge" on the early embryo. The cardiovascular system is extensively remodelled throughout development, this current page only introduces topic.
The heart forms initially in the embryonic disc as a simple paired tube inside the forming pericardial cavity, which when the disc folds, gets carried into the correct anatomical position in the chest cavity.
Throughout the mesoderm, small regions differentiate into "blood islands" which contribute both blood vessels (walls) and fetal red blood cells.
These "islands" connect together to form the first vessels which connect with the heart tube.
A detailed description of heart development is covered in the Online Heart Tutorial.
- Cardiovascular Links: Introduction | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | Coronary Circulation | Heart Valve | Heart Rate | Blood | Blood Vessel | Blood Vessel Histology | Cardiac Histology | Lymphatic | Spleen | Stage 22 | Abnormalities | OMIM | ECHO Meeting | Category:Cardiovascular
Some Recent Findings
- Human Embryology (2nd ed.) Larson Ch7 p151-188 Heart, Ch8 p189-228 Vasculature
- The Developing Human: Clinically Oriented Embryology (6th ed.) Moore and Persaud Ch14: p304-349
- Before we Are Born (5th ed.) Moore and Persaud Ch12; p241-254
- Essentials of Human Embryology Larson Ch7 p97-122 Heart, Ch8 p123-146 Vasculature
- Human Embryology Fitzgerald and Fitzgerald Ch13-17: p77-111
|Begin Basic||Primitive Heart Tube||Embryonic Heart Divisions||Vascular Heart Connections|
|Begin Intermediate||Primordial Heart Tube||Heart Tube Looping||Atrial Ventricular Septation||Outflow Tract||Heart Valves||Cardiac Abnormalities||Vascular Overview|
|Begin Advanced||Heart Fields||Heart Tubes||Cardiac Looping||Cardiac Septation||Outflow Tract||Valve Development||Cardiac Conduction||Cardiac Abnormalities||Molecular Development|
|The Human Heart from day 10 to 25 (scanning electron micrograph)|
- Forms initially in splanchnic mesoderm of prechordal plate region - cardiogenic region
- growth and folding of the embryo moves heart ventrally and downward into anatomical position
- Day 22 - 23, begins to beat in humans
- heart tube connects to blood vessels forming in splanchnic and extraembryonic mesoderm
- Week 2 - 3 pair of thin-walled tubes
- Week 3 paired heart tubes fuse, truncus arteriosus outflow, heart contracting
- Week 4 heart tube continues to elongate, curving to form S shape
- Week 5 Septation starts]], atrial and ventricular
- Septation continues, atrial septa remains open, foramen ovale
- Week 37-38 At birth, pressure difference closes foramen ovale leaving a fossa ovalis
Heart Development Movies
Animations showing aspects of heart development.
|Heart Looping||Heart Realign||Heart Atrial Septation||Heart Outflow Septation|
|Stage 13||Stage 22|
Pages within the online Cardiac tutorial.
|Heart Fields||Primitive Heart Tube||Heart Tubes||Cardiac Looping||Cardiac Septation||Outflow Tract|
|Page | Play|
Historic animations including audio descriptions. Some of these descriptions may be currently inaccurate, the transfer is from an old class film and the audio track is of very poor quality.
|Part 1||Part 2||Part 3||Part 4|
|Part 5||Part 6||Part 7||Part 8|
Ventricular septation rotation models.
|Part 1||Part 2||Part 3|
Chicken Heart Development
Pharyngeal Arch Arteries
In the head region of the embryo, each pharyngeal arch initially has paired arch arteries. These are extensively remodelled through development and give rise to a range of different arterial structures, as shown in the list below.
- Arch 1 - mainly lost, form part of maxillary artery.
- Arch 2 - stapedial arteries.
- Arch 3 - common carotid arteries, internal carotid arteries.
- Arch 4 - left forms part of aortic arch, right forms part right subclavian artery.
- Arch 6 - left forms part of left pulmonary artery , right forms part of right pulmonary artery.
- Links: Head Development
Renal Venous Development
The renal arterial and venous systems are also reorganised extensively throughout development with changing kidney position.
|Embryo renal venous||Adult renal venous|
- Links: Renal Development
Fetal Blood Flow
Mean Late Fetal Blood Flows
(8 subjects) in the major vessels of the human fetal circulation by phase contrast MRI. (median gestational age 37 weeks, age range of 30–39 weeks)
|(left) Mean flows in ml/kg/min||(right) Proportions of the combined ventricular output in the major vessels of the human fetal circulation by phase contrast MRI.|
- Cardiovascular Links: Fetal Blood Flow values | Mean Fetal Blood Flow | Proportions combined ventricular output |
- ↑ Yasuo Ishii, Jonathan Langberg, Kelley Rosborough, Takashi Mikawa Endothelial cell lineages of the heart. Cell Tissue Res.: 2009, 335(1);67-73 PMID:18682987
- ↑ Gert van den Berg, Antoon F M Moorman Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview. PLoS ONE: 2011, 6(7);e22055 PMID:21779373 | PLoS One
- ↑ Mike Seed, Joshua F P van Amerom, Shi-Joon Yoo, Bahiyah Al Nafisi, Lars Grosse-Wortmann, Edgar Jaeggi, Michael S Jansz, Christopher K Macgowan Feasibility of quantification of the distribution of blood flow in the normal human fetal circulation using CMR: a cross-sectional study. J Cardiovasc Magn Reson: 2012, 14();79 PMID:23181717 | J Cardiovasc Magn Reson.
Robert G Kelly The second heart field. Curr. Top. Dev. Biol.: 2012, 100();33-65 PMID:22449840
Peter Carmeliet, Rakesh K Jain Molecular mechanisms and clinical applications of angiogenesis. Nature: 2011, 473(7347);298-307 PMID:21593862
S Degani Fetal cerebrovascular circulation: a review of prenatal ultrasound assessment. Gynecol. Obstet. Invest.: 2008, 66(3);184-96 PMID:18607112
M Tchirikov, H J Schröder, K Hecher Ductus venosus shunting in the fetal venous circulation: regulatory mechanisms, diagnostic methods and medical importance. Ultrasound Obstet Gynecol: 2006, 27(4);452-61 PMID:16565980
Torvid Kiserud Physiology of the fetal circulation. Semin Fetal Neonatal Med: 2005, 10(6);493-503 PMID:16236564
Torvid Kiserud, Ganesh Acharya The fetal circulation. Prenat. Diagn.: 2004, 24(13);1049-59 PMID:15614842
Ronny S Jiji, Christopher M Kramer Cardiovascular magnetic resonance: applications in daily practice. Cardiol Rev: , 19(5);246-54 PMID:21808168
Domenico Ribatti, Valentin Djonov Angiogenesis in development and cancer today. Int. J. Dev. Biol.: 2011, 55(4-5);343-4 PMID:21732277
Anthony Cammarato, Christian H Ahrens, Nakissa N Alayari, Ermir Qeli, Jasma Rucker, Mary C Reedy, Christian M Zmasek, Marjan Gucek, Robert N Cole, Jennifer E Van Eyk, Rolf Bodmer, Brian O'Rourke, Sanford I Bernstein, D Brian Foster A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS ONE: 2011, 6(4);e18497 PMID:21541028
Jeong-Ki Min, Hongryeol Park, Hyun-Jung Choi, Yonghak Kim, Bo-Jeong Pyun, Vijayendra Agrawal, Byeong-Wook Song, Jongwook Jeon, Yong-Sun Maeng, Seung-Sik Rho, Sungbo Shim, Jin-Ho Chai, Bon-Kyoung Koo, Hyo Jeong Hong, Chae-Ok Yun, Chulhee Choi, Young-Myoung Kim, Ki-Chul Hwang, Young-Guen Kwon The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J. Clin. Invest.: 2011, 121(5);1882-93 PMID:21540552
Chaoshe Guo, Ye Sun, Bin Zhou, Rosalyn M Adam, XiaoKun Li, William T Pu, Bernice E Morrow, Anne Moon, Xue Li A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J. Clin. Invest.: 2011, 121(4);1585-95 PMID:21364285
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External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name.
- Australia Heart Foundation
- USA National Heart, Lung, and Blood Institute - Congenital Heart Defects | Heart and Vascular Information
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