File:Disomic XY spermatozoa.jpg

Disomic XY Spermatozoa

Disomic XY sperm, with green X signal, red Y signal and a single blue chromosome 1 signal (an internal control to distinguish disomy from diploidy).

The human sperm–hamster oocyte fusion system allowed the first analysis of human sperm chromosomes. (PMID8941373)

"These studies have greatly improved our information on somatic chromosomal abnormalities such as translocations, inversions and sex chromosomal anomalies, and their consequences to the cytogenetic make-up of human sperm. Also, we have learned that infertile men with a normal somatic karyotype have an increased risk of chromosomally abnormal sperm and children. New techniques such as single sperm typing and synaptonemal complex analysis have provided valuable insight into the association between meiotic recombination and the production of aneuploid sperm. These meiotic studies have also unveiled errors of chromosome pairing and synapsis, which are more common in infertile men."

Original File Name: Figure 2

Reference

<pubmed>18535003</pubmed>| PMC2423221 | Hum Reprod Update.

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