File:Chicken-limb sox9 wnt6.jpg
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Comparison of the expression domains of Sox9 and Wnt6 in the limb
Slightly oblique transverse sections of wing buds at HH-stage 24. (approx 4.5 days)
A Sox9 expression is limited to the chondrogenic region, which is located in the center of the limb bud mesenchyme.
B Wnt6 is expressed in the entire circumference of the limb bud ectoderm.
Scale bar 500 μm
- "Our results suggest that the inhibitory influence of the ectoderm on limb chondrogenesis acts on an early stage of chondrogenesis upsteam of Sox9 and Collagen II. We identify Wnt6 as a candidate mediator of ectodermal chondrogenic inhibition in vivo. We propose a model of Wnt-mediated centripetal patterning of the limb by the surface ectoderm."
Links: Chicken Development | Wnt | Limb Development | Cartilage Development
Original File name: Figure 4. http://www.biomedcentral.com/1471-213X/10/32/figure/F4
Reference
<pubmed>20334703</pubmed>| PMC2859743 | BMC Dev. Biol.
Geetha-Loganathan et al. BMC Developmental Biology 2010 10:32 doi:10.1186/1471-213X-10-32
© 2010 Geetha-Loganathan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:01, 22 September 2010 | | 1,173 × 373 (68 KB) | S8600021 (talk | contribs) | ==Comparison of the expression domains of Sox9 and Wnt6 in the limb== Slightly oblique transverse sections of wing buds at HH-stage 24. (approx 4.5 days) A Sox9 expression is limited to the chondrogenic region, which is located in the center of the limb |
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