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Nat Rev Genet. 2012 Jun 18;13(7):493-504. doi: 10.1038/nrg3245. Human aneuploidy: mechanisms and new insights into an age-old problem. Nagaoka SI1, Hassold TJ, Hunt PA. Author information Abstract Trisomic and monosomic (aneuploid) embryos account for at least 10% of human pregnancies and, for women nearing the end of their reproductive lifespan, the incidence may exceed 50%. The errors that lead to aneuploidy almost always occur in the oocyte but, despite intensive investigation, the underlying molecular basis has remained elusive. Recent studies of humans and model organisms have shed new light on the complexity of meiotic defects, providing evidence that the age-related increase in errors in the human female is not attributable to a single factor but to an interplay between unique features of oogenesis and a host of endogenous and exogenous factors. PMID 22705668 [PubMed - indexed for MEDLINE] PMCID: PMC3551553

Licensee: Mark A Hill License Date: May 10, 2015 License Number: 3625630797711 Publication: Nature Reviews Genetics Title: Human aneuploidy: mechanisms and new insights into an age-old problem Type Of Use: post on a website