File:Male testosterone and AMH level graph.jpg

Human Male Testosterone and Anti-Müllerian Hormone (AMH) levels

• AMH - anti-Müllerian hormone (Müllerian inhibiting factor (MIF), Müllerian-inhibiting hormone (MIH), and Müllerian-inhibiting substance (MIS)).
• T - testosterone

• AMH production remains high during foetal life and childhood and is downregulated at puberty.
• decline of AMH production by Sertoli cells is related to the stage of pubertal development
  • most significant decrease in serum AMH is observed between stages II and III of pubertal development

"in coincidence with the increase of intratesticular testosterone concentration: the decline in AMH production is a marker of the elevation of intratesticular androgen concentration, which inhibits AMH production at puberty. Independently from androgen action, meiotic germ cells seem to play a role in downregulation of AMH expression at puberty. Interestingly, AMH is not down-regulated by testosterone during foetal life and in the first months after birth owing to the lack of expression of the androgen receptor in Sertoli cells (30). The physiological androgen insensitivity of foetal and neonatal Sertoli cells explains, thus, the transient coexistence of high concentrations of androgens and AMH (figure 4). In the absence of the negative effect of androgens and meiotic germ cells (e.g. in foetal and neonatal periods), FSH upregulates testicular AMH production. On one hand, FSH induces Sertoli cell proliferation and, on the other, it enhances AMH transcription in each Sertoli cell through a cAMP-PKA mediated signalling pathway involving transcription factors AP2 and NFB, which bind to specific response elements in distant sequences of the AMH promoter." (text from reference)

Links: AMH | Genital - Male Development | puberty

Reference

Rey R. (2005). Anti-Müllerian hormone in disorders of sex determination and differentiation. Arq Bras Endocrinol Metabol , 49, 26-36. PMID: 16544032 DOI.

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Cite this page: Hill, M.A. (2024, April 26) Embryology Male testosterone and AMH level graph.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Male_testosterone_and_AMH_level_graph.jpg

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