File:Fluorescence In situ Hybridization (FISH) assay.JPG

This is a FISH (fluorescence in situ hybridization) analysis X chromosomes within a mosaic nucleus of XXY, XXXY, and XXXXY respectively. Each section (out of the three shown)illustrates a single nucleus. Within each nucleus the X chromosomes have been marked with a green fluoresent protein, allowing for their observation. As can be seen, the first nucleus is of standard Klinefelter's karyotype with two X chromosomes, and so on. These cells were isolated from a single patient expressing mosaic Klinefelter's syndrome.

Reference

Jesús E Dueñas-Arias, Maribel Aguilar-Medina, Eliakym Arámbula-Meraz, Juliana B Valenzuela-Camacho, Angelina Vega-Solano, Julio Granados, Rosalío Ramos-Payán 47,XXY/48,XXXY/49,XXXXY mosaic with hydrocephaly: a case report and review of the literature. J Med Case Reports: 2007, 1();94 PMID:17880714 | PMC3105055

Copyright - © 2007 Dueñas-Arias et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Assessment

+ Research image is very relevant to group topic. +/- The legend does describe what is shown in the figure, but it is not an accurate description (what is the red fluorescence?) and therefore does not provide a complete element of peer teaching. - No assessment of citation included as reformatted by coordinator. Mark Hill 19:05, 1 October 2011 (EST) I have reformatted the citation. Please follow the methodology as I have advised you in class before. Please add a more complete description of the image above.

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