File:3D Human pancreatic islet.jpg

Three-dimensional Analysis of Human Pancreatic Islet

• Consecutive sections through an entire adult pancreatic islet labeled for insulin (red) and glucagon (green).
• Images show that insulin (red) and glucagon (green) stained cells are organized into continuous 3-D networks that span the entire islet.
• Sections at both ends show islet profiles with an apparent similar core-mantle structure to that of 40- to 60-μm–diameter islets.
• These consecutive images also reveal that vascular channels were in fact continuous ramified structures that were connected in places with the surrounding islet tissue (arrowheads).
• Image series is representative of 15 different pancreatic islets analyzed from one pancreas.

Scale bar, 50 μm.

Links: Image - Islet Insulin and Glucagon | Endocrine - Pancreas Development

Original file name: FIG. 4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857900/figure/F4/ http://diabetes.diabetesjournals.org/content/59/5/1202/F4.large.jpg

Reference

Domenico Bosco, Mathieu Armanet, Philippe Morel, Nadja Niclauss, Antonino Sgroi, Yannick D Muller, Laurianne Giovannoni, Géraldine Parnaud, Thierry Berney Unique arrangement of alpha- and beta-cells in human islets of Langerhans. Diabetes: 2010, 59(5);1202-10 PMID:20185817 | PMC2857900 | Diabetes.

© 2010 by the American Diabetes Association

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