File:Human thyroid system and neural development.jpg
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Human Thyroid System Development
Timeline of human thyroid system and brain development from conception to birth. Estimation of neurogenesis adapted from Bayer et al. (1993).
- Development of the human thyroid gland begins in the third week of gestation.
- GD 16-17 - embryonic thyroid is visible as an outgrowth in the floor of the primitive buccal cavity (the site of the future pharynx).
- Additional lateral contributions to the embryonic thyroid originate from a portion of the fourth pharyngeal pouches; these lateral contributions are the origin of the C-cells, which produce calcitonin.
- GD29 - thyroglobulin (TBG), the precursor protein upon which thyroid hormone is produced and stored, is initially detected in thyroid follicle cells.
- GD45-50 - thyroid gland tissues merge and migrate to their final location.
- GD70 - thyroid gland is well developed; it begins concentrating iodide and producing thyroid hormone at this time (3).
- GW11 - TBG levels are detected in fetal serum as thyroid follicle cells mature, and continues to increase through gestation.
GD = gestation day
GW = gestational week
TBG = thyroglobulin
Reference
Howdeshell KL. (2002). A model of the development of the brain as a construct of the thyroid system. Environ. Health Perspect. , 110 Suppl 3, 337-48. PMID: 12060827
Bayer SA, Altman J, Russo RJ & Zhang X. (1993). Timetables of neurogenesis in the human brain based on experimentally determined patterns in the rat. Neurotoxicology , 14, 83-144. PMID: 8361683
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Cite this page: Hill, M.A. (2024, May 21) Embryology Human thyroid system and neural development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Human_thyroid_system_and_neural_development.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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File usage
The following 10 pages use this file:
- ANAT2341 Lab 10 - Fetal
- Abnormal Development - Iodine Deficiency
- BGDA Lecture - Development of the Nervous System
- Endocrine - Thyroid Development
- Lecture - Fetal Development
- Lecture - Neural Development
- Neural System - Fetal
- Neural System Development
- REI - Reproductive Medicine Seminar 2018
- Royal Hospital for Women - Reproductive Medicine Seminar 2018