Movie - Mouse Lymph Node 4

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Adult Mouse Lymph Node - T cells within the medullary sinus. Single T cell traversing the sinus endothelial barrier.

Movies show lymphocyte traffic through adult lymph nodes. Cells were isolated from spleens and lymph nodes of BALB/c mice.

T Cell Movies: Transendothelial migration | T cell zone | Medullary sinus | Sinus endothelial barrier | Bi-directional traffic | cross the sinus endothelial barrier | T and B cell motility

Links: Immune System Development | Lymph Node Development

References

Sindy H Wei, Hugh Rosen, Melanie P Matheu, M Germana Sanna, Sheng-Kai Wang, Euijung Jo, Chi-Huey Wong, Ian Parker, Michael D Cahalan Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol.: 2005, 6(12);1228-35 PMID:16273098 | Immunology Michael D Cahalan, Ian Parker Choreography of cell motility and interaction dynamics imaged by two-photon microscopy in lymphoid organs. Annu. Rev. Immunol.: 2008, 26();585-626 PMID:18173372

Movie Source

Michael D. Cahalan, Professor and Chair, Department of Physiology and Biophysics, University of California, Irvine. Lab Two-photon imaging movies reproduced with permission of Prof. Cahalan.