Gastrointestinal Tract - Gall Bladder Histology

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Introduction

Gall bladder transverse section historic drawing.

This section of notes gives an overview mainly of adult gall bladder histology, see also Gall Bladder Development notes.

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Page also provides further background information for Medicine phase 1 Health Maintenance B Hepatobiliary System 2 Practical Virtual Slides. This page content is not part of the HMB practical class.


HMB: Pancreas Histology | Liver Histology | Gall Bladder Histology | Renal System Histology


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Historic Embryology
1878 Alimentary Canal | 1882 The Organs of the Inner Germ-Layer The Alimentary Tube with its Appended Organs | 1902 The Organs of Digestion | 1907 Development of the Digestive System | 1907 Atlas | 1907 23 Somite Embryo | 1912 Digestive Tract | 1917 Entodermal Canal | 1918 Anatomy | 1921 Alimentary Tube | 2014 GIT Notes | Historic Disclaimer
Human Embryo: 1908 13-14 Somite Embryo | 1926 22 Somite Embryo | 1907 23 Somite Embryo | 1937 25 Somite Embryo | 1914 27 Somite Embryo | 1914 Week 7 Embryo
Animal Development: 1913 Chicken | 1951 Frog

Lab Audio

Podcast icon.jpg Wednesday 24 August 2011 3-3:30 pm G2G4.


Links: listen 1 | download 1 | listen 2 | download 2 | listen 3 | download 3 | listen 4 | download 4 | Gall Bladder Histology Background


Gall Bladder Structure

Anatomy

  • Pear-shaped
  • distensible sac (about 50ml volume)
  • Attached to posterioinferior surface of liver
  • Embryonic - foregut, forms from primitive bile duct
  • leads to cystic duct
    • Liver -> hepatic duct
    • Gall bladder -> cystic duct
    • Common Bile duct


Macroscopic Mucosal features:

  • Mucosa (epithelium + lamina propria)
    • Mucosal folds
    • Rokintansky-Aschoff sinuses
  • Serosa/Adventitia (dense CT + visceral mesothelium)

Epithelium

  • Columnar epithelium with microvilli (absorptive epithelium)
    • Epithelium lining the biliary system does not contain mucus-producing cells (few located in neck of gall bladder)
  • Basement membrane (not basal lamina which forms part of basement membrane and only visible by EM)

Lamina Propria

  • connective tissue
  • collagen fibers and fibroblasts
  • fenestrated capillaries and venules
  • lymphocytes and plasma cells

Smooth Muscle Layer

  • random orientation of smooth muscle cells (fibers)
  • muscularis propria (or fibromuscular coat)[1]
    • not like the rest of GIT smooth muscle organisation, which is divided into muscularis mucosa (inside submucosa), muscularis externa (circular and longitudinal)
    • various terminology used for this layer in different sources

Serosa/Adventitia

  • Dense connective tissue layer covered with visceral mesothelium epithelial layer
    • Adventitia - where it is attached to the liver
    • Serosa - where it is free in the peritoneum
  • Large blood vessels (arteries, veins)
  • Obvious lymphatic vessels
  • Autonomic nerve bundles
  • Adipose tissue

Gall Bladder Function

  • bile storage
  • bile concentration
  • bile release

Histology Images

Development Histology

Adult Histology

Gall bladder histology 001.jpg Gall bladder histology 002.jpg

Gall bladder histology 003.jpg Gall bladder histology 004.jpg


See also Animated labeled image

References

  1. Kirtee Raparia, Qihui J Zhai, Mary R Schwartz, Steven S Shen, Alberto G Ayala, Jae Y Ro Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study. Ann Diagn Pathol: 2010, 14(6);408-12 PMID:21074688

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Cite this page: Hill, M.A. (2014) Embryology Gastrointestinal Tract - Gall Bladder Histology. Retrieved July 23, 2014, from //php.med.unsw.edu.au/embryology/index.php?title=Gastrointestinal_Tract_-_Gall_Bladder_Histology

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Dr Mark Hill 2014, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G