Gastrointestinal Tract - Gall Bladder Histology

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Contents

Introduction

Gall bladder transverse section historic drawing.

This section of notes gives an overview mainly of adult gall bladder histology, see also Gall Bladder Development notes.

HMsmall.jpg
Page also provides further background information for Medicine phase 1 Health Maintenance B Hepatobiliary System 2 Practical Virtual Slides. This page content is not part of the HMB practical class.


HMB: Pancreas Histology | Liver Histology | Gall Bladder Histology | Renal System Histology


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GIT Histology Links: Upper GIT | Salivary Gland | Smooth Muscle Histology | Liver | Gall Bladder | Pancreas | Colon | Histology Stains | Histology | GIT Development

Lab Audio

Podcast icon.jpg Wednesday 24 August 2011 3-3:30 pm G2G4.


Links: listen 1 | download 1 | listen 2 | download 2 | listen 3 | download 3 | listen 4 | download 4 | Gall Bladder Histology Background


Gall Bladder Structure

Anatomy

  • Pear-shaped
  • distensible sac (about 50ml volume)
  • Attached to posterioinferior surface of liver
  • Embryonic - foregut, forms from primitive bile duct
  • leads to cystic duct
    • Liver -> hepatic duct
    • Gall bladder -> cystic duct
    • Common Bile duct


Macroscopic Mucosal features:

  • Mucosa (epithelium + lamina propria)
    • Mucosal folds
    • Rokitansky-Aschoff sinuses
  • Serosa/Adventitia (dense CT + visceral mesothelium)

Epithelium

  • Columnar epithelium with microvilli (absorptive epithelium)
    • Epithelium lining the biliary system does not contain mucus-producing cells (few located in neck of gall bladder)
  • Basement membrane (not basal lamina which forms part of basement membrane and only visible by EM)

Lamina Propria

  • connective tissue
  • collagen fibers and fibroblasts
  • fenestrated capillaries and venules
  • lymphocytes and plasma cells

Smooth Muscle Layer

  • random orientation of smooth muscle cells (fibers)
  • muscularis propria (or fibromuscular coat)[1]
    • not like the rest of GIT smooth muscle organisation, which is divided into muscularis mucosa (inside submucosa), muscularis externa (circular and longitudinal)
    • various terminology used for this layer in different sources

Serosa/Adventitia

  • Dense connective tissue layer covered with visceral mesothelium epithelial layer
    • Adventitia - where it is attached to the liver
    • Serosa - where it is free in the peritoneum
  • Large blood vessels (arteries, veins)
  • Obvious lymphatic vessels
  • Autonomic nerve bundles
  • Adipose tissue

Gall Bladder Function

  • bile storage
  • bile concentration
  • bile release

Histology Images

Development Histology

Adult Histology

Gall bladder histology 001.jpg Gall bladder histology 002.jpg

Gall bladder histology 003.jpg Gall bladder histology 004.jpg


See also Animated labeled image

References

  1. Kirtee Raparia, Qihui J Zhai, Mary R Schwartz, Steven S Shen, Alberto G Ayala, Jae Y Ro Muscularis mucosae versus muscularis propria in gallbladder, cystic duct, and common bile duct: smoothelin and desmin immunohistochemical study. Ann Diagn Pathol: 2010, 14(6);408-12 PMID:21074688

External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name.


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Cite this page: Hill, M.A. (2014) Embryology Gastrointestinal Tract - Gall Bladder Histology. Retrieved April 18, 2014, from http://embryology.med.unsw.edu.au/embryology/index.php?title=Gastrointestinal_Tract_-_Gall_Bladder_Histology

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Dr Mark Hill 2014, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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