File:T2 lymphocyte EM14.jpg

T Lymphocyte Electron Micrograph

Effector T cell has relatively little cytoplasmic rough endoplasmic reticulum (RER) but is filled with free ribosomes.

Cytotoxic T lymphocytes (CTLs) (killer T cells) - directly attack other cells carrying certain foreign or abnormal molecules on their surfaces. CTLs are especially useful for attacking viruses because viruses often hide from other parts of the immune system while they grow inside infected cells. CTLs recognize small fragments of these viruses peeking out from the cell membrane and launch an attack to kill the infected cell.

Helper T cells (Th cells) - coordinate immune responses by communicating with other cells. Some stimulate nearby B cells to produce antibodies, others call in microbe-gobbling cells called phagocytes, and still others activate other T cells.

(NAIAD text)

Fig. 14. Lymph node cells (4 days after immunization with DBA/2 mastocytoma) labeled with aBA0 followed by SaRIg-Pox. This cell classified as T2 lymphocyte is characterized by its large content in polyribosomes, often forming "rosettes," and by an enveloping filamentous network (fn) , appearing at this magnification as a peripheral greyish area.

X 18,500.

Note this T2/T3 terminology may now be historic.

Lymphocyte EM Images: T and B Lymphocytes 1 TEM | T and B Lymphocytes 2 TEM | T Lymphocyte SEM | B lymphocyte 1 TEM | B lymphocyte 2 TEM | B lymphocyte 3 TEM | Plasma Cell TEM | T2 Lymphocyte 1 TEM | T2 Lymphocyte 2 TEM | lymphocyte rosettes | T lymphocyte 1 | T lymphocyte 2 | T lymphocyte 3 | T lymphocyte 4 | T lymphocyte 5 | T lymphocyte 6 | B lymphocyte | B lymphocytes TEM | Immune System Development | Blood

Reference

Matter A, Lisowska-Bernstein B, Ryser JE, Lamelin JP & Vassalli P. (1972). Mouse thymus-independent and thymus-derived lymphoid cells. II. Ultrastructural studies. J. Exp. Med. , 136, 1008-30. PMID: 4563148

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