File:Skull - osteoblast lineage model.jpg

Skull Osteoblast Lineage Model

Model for osteoblast lineage development mediated by the Axin2/β-catenin/cyclin D1 regulatory pathway.

Growing evidence suggests that Axin2/β-catenin regulates the self renewal of mesenchymal stem cells (MSCs) and the expansion of skeletogenic progenitors during calvarial morphogenesis.

This study shows that cyclin D1 is a downstream modulator, acting in this regulatory axis. Furthermore, canonical Wnt signaling promotes specification of osteoprogenitors which are Runx2+ and Osx+, but prohibits terminal differentiation of mature osteoblasts expressing high levels of Op. Nonetheless, osteoblasts expressing low levels of Op are matrix-secreting cells capable of mediating bone synthesis.

Links: skull | bone

Reference

Mirando AJ, Maruyama T, Fu J, Yu HM & Hsu W. (2010). β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev. Biol. , 10, 116. PMID: 21108844 DOI.

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© 2010 Mirando et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

http://www.biomedcentral.com/1471-213X/10/116

Mirando et al. BMC Developmental Biology 2010 10:116 doi:10.1186/1471-213X-10-116

Original file name: Figure 9. 1471-213X-10-116-9-l.jpg

Cite this page: Hill, M.A. (2024, April 20) Embryology Skull - osteoblast lineage model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Skull_-_osteoblast_lineage_model.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G