File:Polycystic kidney disease cartoon.jpg
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Cyst formation at the level of the cell, nephron, and kidney
- Defects in the genes encoding PC1 or PC2 lead to aberrant gene transcription, cell proliferation, and ion secretion, which in turn result in the formation of fluid-filled cysts.
- As cysts balloon out from individual nephrons, their collective effect leads to the displacement of the normal renal parenchyma and the formation of a cyst-filled kidney with reduced functional capacity.
Reference
<pubmed>21079243</pubmed>| JCB
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| current | 21:42, 6 March 2012 | | 1,280 × 486 (120 KB) | Z8600021 (talk | contribs) | ==Cyst formation at the level of the cell, nephron, and kidney== * Defects in the genes encoding PC1 or PC2 lead to aberrant gene transcription, cell proliferation, and ion secretion, which in turn result in the formation of fluid-filled cysts. * As cys |
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