File:Mouse ruga pattern.jpg
Mouse Palate Adult and E16
Mouse adult ruga pattern and its visualization in the fetus by in situ hybridization against Shh gene.
(A) The roof of the oral cavity of an adult mouse showing the palatal ridges (rugae palatinae) on the hard palate.
(B) Mouse rugae pattern with numbering used in this study. Note that ruga 7b was called 8b in other studies (Peterkova et al. 1987; Charles et al. 2007).
(C) In ED16.0 fetus, Shh gene expression pattern (as seen by whole-mount in situ hybridization) prefigures the adult ruga pattern.
(D) Sagittal section through the same embryo as in C, showing Shh expression in the epithelium at the tip of rugae (see magnification in the low left corner). The absence of Shh signal in the rugae 1–4 can be explained by its discontinuity in the anterior rugae at this stage (see C).
- "We showed that palatal rugae are sequentially added to the growing palate, in an interposition process that appears to be dependent on activation-inhibition mechanisms and reveals a new developmental boundary in the growing palate. Further studies on rugae may help to shed light on both the development and evolution of structures arranged in regular patterns. Moreover, rugae will undoubtedly be powerful tools to further study the anteroposterior regionalization of the growing palate."
Original File Name: Figure 1. 1471-213X-8-116-1.jpg http://www.biomedcentral.com/1471-213X/8/116/figure/F1
Sophie Pantalacci, Jan Prochazka, Arnaud Martin, Michaela Rothova, Anne Lambert, Laure Bernard, Cyril Charles, Laurent Viriot, Renata Peterkova, Vincent Laudet Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development. BMC Dev. Biol.: 2008, 8();116 PMID:19087265 | PMC2637861 | BMC Dev Biol.
Published online 2008 December 16. doi: 10.1186/1471-213X-8-116.
Copyright © 2008 Pantalacci et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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