File:Mouse maternal ethanol skull effects.png

Variable midfacial dysmorphism and microcephaly in a/a offspring of mothers that consumed ethanol during gestation.^[1]

The top panel shows 3D reconstructions of skull microCT data from 28–30 day old mice. (A) Control female. (B) Ethanol-exposed male showing marked leftward deviation of the midface. (C) Ethanol-exposed female showing an almost absent interfrontal bone that is normally characteristic of untreated C57BL6/J mice. (D) Graph of centroid size (used as an estimate of overall cranial size) against body weight for control (n = 10) and ethanol exposed (n = 7) mice at 28–30 days old. Centroid size was determined by summing the distances from each landmark to the centroid for each individual. Centroid size is highly correlated with body weight in both treatment groups, but those in the ethanol group are on average smaller than those in the controls (ANOVA, p<0.05).

Figure 4. Journal.pgen.1000811.g004.png http://www.plosgenetics.org/article/slideshow.action?uri=info:doi/10.1371/journal.pgen.1000811&imageURI=info:doi/10.1371/journal.pgen.1000811.g004

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000811

Reference

Received: June 22, 2009; Accepted: December 10, 2009; Published: January 15, 2010

Copyright

© 2010 Kaminen-Ahola et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this page: Hill, M.A. (2024, April 20) Embryology Mouse maternal ethanol skull effects.png. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_maternal_ethanol_skull_effects.png

What Links Here?

© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G