File:Mouse face Bmp4.mp4

Bmp4 Expression in Mouse Limb and Orofacial Region

Frontal views of the developing head of Bmp4lacZneo transgenic embryos from permanent line TL3459.

From E9.5 to E11.0, Bmp4 is expressed in the epithelium overlying the distal first branchial arch, maxillary and mandibular processes and medial and lateral nasal processes.

Expression in the ectoderm overlying the distal part of the first branchial arch at E9.5 and the mandibular process at E10.5.

At E12.5, endogenous Bmp4 expression shifts to the mesenchyme.

At E12.5 and 13.5, endogenous Bmp4 is concentrated in the mesenchyme of the midface including the whisker follicles.

Abbreviations: MxP, maxillary process; MdP, mandibular process; MNP, medial nasal process; LNP, lateral nasal process; NP, nasal pit; Mx, maxilla; Md, mandible.

BMP Mouse Links: Face and limb E9.5-13.5 | Face E9.5-13.5 | Body E11.0 | Body E11.5 | BMP | Mouse Development

Reference

PLoS One

Citation: Jumlongras D, Lachke SA, O’Connell DJ, Aboukhalil A, Li X, et al. (2012) An Evolutionarily Conserved Enhancer Regulates Bmp4 Expression in Developing Incisor and Limb Bud. PLoS ONE 7(6): e38568. doi:10.1371/journal.pone.0038568

Editor: Songtao Shi, University of Southern California, United States of America

Received: April 4, 2012; Accepted: May 7, 2012; Published: June 12, 2012

Copyright: © 2012 Jumlongras et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

doi:10.1371/journal.pone.0038568.g003

Figure 3. Journal.pone.0038568.g003.jpg

Panels cropped and resized from full figure, above text modified from figure legend, single frames animated.