File:Mouse-forelimb bud Fgf4-Hoxd13-Hoxa13.jpg

Mouse forelimb bud expression of Fgf4, Hoxd13, and Hoxa13

(A) Skeletal preparation (E14.5) wild-type forelimbs. Digit identities are indicated by numbers 1 (thumb, anterior) to 5 (little finger, posterior).

(B) Fgf4 expression in the AER of wild-type limb buds at E10.5 (36 somites). Arrowheads indicate the anterior and posterior margins of limb buds.

(C) Hoxd13 expression at E10.75 (40 somites). The late Hoxd13 expression domain in H2Δ/ΔcGli3Xt/Xt limb buds appears symmetrical in contrast to e.g. Gli3 deficient limb buds (expression borders are indicated by red lines). This is best seen by comparing apical views.

(D) Hoxa13 expression at E10.75 (41 somites). The Hoxa13 expression domain appears also symmetrical in H2Δ/ΔcGli3Xt/Xt limb buds, while some asymmetry is retained in Gli3 deficient limb buds

(red lines in dorsal views; best seen by comparing the apical views).

Original File name: Journal.pgen.1000901.g003.png Excerpt from Figure 7. showing only the normal limb gene expression.

Reference

<pubmed>20386744</pubmed>

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