File:Model for cloacal septation 01.jpg
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Model for cloacal septation
(A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line.
(B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.
- Bmp7 - Bone morphogenetic protein 7
- JNK - c-Jun N-terminal kinase pathway
- K14 - Keratin 14 (expression and accumulation marks the maturation of the endodermal epithelium and commitment to stratification)
Reference
Xu K, Wu X, Shapiro E, Huang H, Zhang L, Hickling D, Deng Y, Lee P, Li J, Lepor H & Grishina I. (2012). Bmp7 functions via a polarity mechanism to promote cloacal septation. PLoS ONE , 7, e29372. PMID: 22253716 DOI.
Copyright
© 2012 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 7. Journal.pone.0029372.g007.jpg doi:10.1371/journal.pone.0029372.g007
Cite this page: Hill, M.A. (2024, April 20) Embryology Model for cloacal septation 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_for_cloacal_septation_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:50, 8 June 2012 | | 1,000 × 680 (73 KB) | Z8600021 (talk | contribs) | ==Model for cloacal septation== (A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activ |
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