File:Mechanism of tetrabenazine.jpg
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Mechanism of tetrabenazine inhibition
VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release. By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, unable to travel across the synaptic cleft. Tetrabenazine also binds and inhibit to dopamine receptors. This suppresses the amount of dopamine binding to the dopamine receptor located at the post synaptic nerve terminal. Thus, the neurones will not be stimulated and no cascade for the inducement of kinetic movements will be triggered.
Based upon Tetrabenazine for the Treatment of Huntington’s Chorea
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Cite this page: Hill, M.A. (2024, April 20) Embryology Mechanism of tetrabenazine.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mechanism_of_tetrabenazine.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:43, 20 September 2011 | | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | Reverted to version as of 09:41, 20 September 2011 |
| 19:43, 20 September 2011 |  | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u | |
| 19:41, 20 September 2011 |  | 600 × 459 (33 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u | |
| 20:14, 19 September 2011 |  | 2,448 × 1,872 (221 KB) | Z3389806 (talk | contribs) | ==Mechanism of tetrabenazine inhibition== VMAT2 is the only transporter that transports dopamine from the cytoplasm into synaptic vesicles for storage and eventual release.[92] By inhibiting VMAT2, dopamine will not be packaged into vesicles and hence, u |
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