File:Lymphocyte rosettes EM01-06.jpg

Human Lymphocytes with Sheep Erythrocyte Rosettes

Human lymphocytes (Thymocytes, T-cells) and Sheep erythrocytes (Red Blood Cells, SRBC).

Fig. 1. SRBC washed with HBSS showing spheroechinocyte transformation. Two SRBC have maintained their biconcave shape. X 3,600.

Fig. 2. SRBC showing microspherulation, with multiple microprojections with beaded ends. X 6,900.

Fig. 3. E-rosette showing a smooth surfaced T lymphocyte surrounded by SRBC; the majority of T cells and less than 10% of rosetting B ceils had this type of surface. X 5,700.

Fig. 4. E-rosette showing intermediate type of T lymphocyte.Up to 30% of rosetting B and T cells had this type of surface. X 6,000.

Fig. 5. EAC-rosette, showing villous B cell. The majority of B cells and about 15% of T cells showed this surface morphology.X 5,700.

Fig. 6. Rosetting T lymphocyte with a villous surface, surrounded by spheroechinocyte SRBC which have multiple projections with beaded extremities of similar dimensions to lymphocyte microvilli. This type of picture suggested that deposition of portions of SRBC projections to the lymphocyte surface may occur. X 6,600.

Lymphocyte EM Images: T and B Lymphocytes 1 TEM | T and B Lymphocytes 2 TEM | T Lymphocyte SEM | B lymphocyte 1 TEM | B lymphocyte 2 TEM | B lymphocyte 3 TEM | Plasma Cell TEM | T2 Lymphocyte 1 TEM | T2 Lymphocyte 2 TEM | lymphocyte rosettes | T lymphocyte 1 | T lymphocyte 2 | T lymphocyte 3 | T lymphocyte 4 | T lymphocyte 5 | T lymphocyte 6 | B lymphocyte | B lymphocytes TEM | Immune System Development | Blood

References

Polliack A, Fu SM, Douglas SD, Bentwich Z, Lampen N & De Harven E. (1974). Scanning electron microscopy of human lymphocyte-sheep erythrocyte rosettes. J. Exp. Med. , 140, 146-58. PMID: 4545895

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