File:Implantation cartoon 01.jpg

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Molecular Implantation Cartoon

Compartment colours
This is a hybrid cartoon, based on mouse and human studies, portraying compartment- and cell-type–specific expression of molecules and their potential functions necessary for uterine receptivity, implantation and decidualization. Interplay of ovarian P4- and/or E2-dependent and P4- and/or E2-independent factors in the pregnant uterus in specific compartments contributes to the success of implantation in a juxtacrine/paracrine/autocrine manner. During attachment, interactions between the blastocyst and luminal epithelium (LE) involve ErbB1/4 (blue) and both transmembrane (TM) and soluble (Sol) forms of HB-EGF, as well as L-selectin ligands (sLE) expressed by the luminal epithelium to L-selectin receptors on the blastocyst. The other key signaling pathways for uterine receptivity and implantation are also shown.
  • blue - stroma
  • pink - luminal epithelium
  • orange - glandular epithelium
  • purple - epithelium at the attachment site.
Legend
  • AA - arachidonic acid
  • BMP2 - bone morphogenetic protein 2
  • cPLA2α - cytosolic phospholipase A2α
  • COUP-TFII - chicken ovalbumin upstream promoter transcription factor-2
  • Cox2 - cyclooxygenase-2
  • E - estrogens
  • EC - epithelial cell (luminal and glandular epithelia)
  • ENaC - epithelium sodium channel
  • ER - estrogen receptor
  • ErbB1/4 - epidermal growth factor receptor 1/4
  • ERK - extracellular signal–regulated kinase
  • FGF - fibroblast growth factor
  • GE - glandular epithelium
  • gp130 - glycoprotein 130
  • Hand2 - heart- and neural crest derivatives-expressed protein 2
  • HB-EGF - heparin-binding epidermal growth factor-like growth factor
  • Hoxa10/11 - homeobox A10/11
  • ICM - inner cell mass
  • IHH - Indian hedgehog
  • KLF5 - Kruppel-like factor 5
  • LIF - leukemia inhibitory factor
  • LIFR - LIF receptor
  • LPA3 - lysophosphatidic acid receptor 3
  • MSX1 - Muscle segment homeobox 1
  • P4 - progesterone
  • PG - prostaglandin
  • PPAR-δ - peroxisome proliferators–activating receptor δ
  • PR - progesterone receptor
  • Ptc - Patched
  • RXR - retinoid X receptor
  • SC - stromal cell
  • SGK1 - serum- and glucocorticoid-inducible kinase 1
  • Smo - Smoothened
  • STAT3 - signal transducer and activator of transcription 3
  • Tr - trophectoderm
  • Wnt4/5a - Wingless-Type MMTV integration site family members 4/5a.


Links: Implantation


Reference

Cha J, Sun X & Dey SK. (2012). Mechanisms of implantation: strategies for successful pregnancy. Nat. Med. , 18, 1754-67. PMID: 23223073 DOI.

Copyright

Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Mechanisms of implantation: strategies for successful pregnancy. Cha J, Sun X, Dey SK. Nat Med. 2012 Dec;18(12):1754-67. doi: 10.1038/nm.3012. Review. PMID 23223073), copyright (2012)

Nm.3012-F1.jpg

Cite this page: Hill, M.A. (2024, April 19) Embryology Implantation cartoon 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Implantation_cartoon_01.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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