File:Implantation LIF.jpg
Implantation_LIF.jpg (800 × 325 pixels, file size: 48 KB, MIME type: image/jpeg)
Uterine Leukemia Inhibitory Factor (LIF) Expression
| a - Day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen.
There, LIF binds to its receptors on the surface of epithelial cells. |
b- Day 5 uterus receptive to the blastocyst, which implants by day 5 of pregnancy.
Hu et al. find that LIF expression in the endometrial glands also depends on the regulatory activity of p53. In the absence of p53, insufficient LIF is produced, the uterus does not become adequately receptive, and fewer blastocysts implant. |
- Links: Implantation
Reference
Hu W, Feng Z, Teresky AK & Levine AJ. (2007). p53 regulates maternal reproduction through LIF. Nature , 450, 721-4. PMID: 18046411 DOI.
http://www.nature.com/nrg/journal/v7/n3/full/nrg1808.html
Copyright
Image source: News and Views - Stewart, CL Nature 450, 619 (29 November 2007) by permission from Macmillan Publishers Ltd (copyright 2007) p53 regulates maternal reproduction through LIF. Nature. 2007 Nov 29;450(7170):721-4.)
Cite this page: Hill, M.A. (2024, April 19) Embryology Implantation LIF.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Implantation_LIF.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 12:46, 7 November 2009 | | 800 × 325 (48 KB) | S8600021 (talk | contribs) | a At day 4 of pregnancy, oestrogen E2 induces LIF expression in the endometrial glands, leading to LIF secretion into the uterine lumen. There, LIF binds to its receptors on the surface of epithelial cells. bThis makes the uterus receptive to the blasto |
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