File:3D virtual muscle model 01.jpg

Spatial gene expression of muscle cell using the VMus3D (myoblast to myotube)

The VMus3D demonstrating the spatial gene expression profile of the structure of skeletal muscle from myoblast to myotube.

Colours are coded according to gene expression log ratios:

• yellow - less than two
• purple - greater than two but less than five
• blue - greater than five

The filament system demonstrated mostly large changes in gene expression whilst other structural locations did not. Waardenberg et al. BMC Systems Biology 2008 2:88 doi:10.1186/1752-0509-2-88

Original file name: Figure 1. 1752-0509-2-88-1.jpg http://www.biomedcentral.com/1752-0509/2/88/figure/F1

"Myogenesis is an ordered process whereby mononucleated muscle precursor cells (myoblasts) fuse into multinucleated myotubes that eventually differentiate into myofibres, involving substantial changes in gene expression and the organisation of structural components of the cells. To gain further insight into the orchestration of these structural changes we have overlaid the spatial organisation of the protein components of a muscle cell with their gene expression changes during differentiation using a new 3D visualisation tool: the Virtual Muscle 3D (VMus3D)."

Reference

<pubmed>18945372</pubmed>| PMC2596796 | BMC Syst Biol.

© 2008 Waardenberg et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.