Abnormal Development - Lymphocytic Choriomeningitis Virus
Contents |
Introduction
Lymphocytic choriomeningitis virus (LCMV) is carried by wild mice (Mus musculus). Laboratory rodents and pet rodents, such as rats, mice, hamsters and guinea pigs, can become infected with LCMV from contact with wild mice. This can happen in a breeding facility, in a laboratory facility, in a pet store, or in the home if wild mice are present. Humans can be infected through exposure to rodent excreta. In the rat animal model, the virus appears to selectively infect mitotically active neuronal precursors, while glial cells may also have a role in the initial entry, replication, and dispersion.
Maternal infection can be transferred placental to fetus and can result in either loss or birth defects (hydrocephalus, chorioretinitis or deafness). Since LCMV infection was first identified, more than 50 babies have been reported with LCMV infection worldwide.
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Some Recent Findings
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Virus Structure
Lineage: Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; Old world arenaviruses; Lymphocytic choriomeningitis virus
- Lymphocytic choriomeningitis virus (strain Armstrong)
- Lymphocytic choriomeningitis virus (strain Pasteur)
- Lymphocytic choriomeningitis virus (strain Traub)
- Lymphocytic choriomeningitis virus (strain WE)
- Links: Genome
Virus Detection
Diagnosis of congenital LCMV infection can be confirmed in infants by immunofluorescence antibody (IFA)[3], enzyme-linked immunosorbent assays (ELISAs) or quantitative polymerase chain reaction (QPCR, or real time PCR (rtPCR)).[4]
References
- ↑ Daniel J Bonthius, Stanley Perlman Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. PLoS Pathog.: 2007, 3(11);e149 PMID:18052527 | PLoS Pathog.
- ↑ J F Meritet, A Krivine, F Lewin, M H Poissonnier, R Poizat, P Loget, F Rozenberg, P Lebon A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis. Prenat. Diagn.: 2009, 29(6);626-7 PMID:19253314
- ↑ V J Lewis, P D Walter, W L Thacker, W G Winkler Comparison of three tests for the serological diagnosis of lymphocytic choriomeningitis virus infection. J. Clin. Microbiol.: 1975, 2(3);193-7 PMID:1100673
- ↑ Megan M McCausland, Shane Crotty Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J. Virol. Methods: 2008, 147(1);167-76 PMID:17920702
Textbooks
- Medical Microbiology. 4th edition. Baron S, editor. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Search Medical Microbiology Lymphocytic choriomeningitis virus
- Molecular Biology of the Cell. 4th edition. Alberts B, Johnson A, Lewis J, et al. New York: Garland Science; 2002. Viruses Exploit Host Cell Machinery for All Aspects of Their Multiplication
- Disease Control Priorities in Developing Countries. 2nd edition. Jamison DT, Breman JG, Measham AR, et al., editors. Washington (DC): World Bank; 2006. Chapter 20Vaccine-preventable Diseases
Reviews
Denise J Jamieson, Athena P Kourtis, Michael Bell, Sonja A Rasmussen Lymphocytic choriomeningitis virus: an emerging obstetric pathogen? Am. J. Obstet. Gynecol.: 2006, 194(6);1532-6 PMID:16731068
R Wright, D Johnson, M Neumann, T G Ksiazek, P Rollin, R V Keech, D J Bonthius, P Hitchon, C F Grose, W E Bell, J F Bale Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. Pediatrics: 1997, 100(1);E9 PMID:9200383
Articles
Megan M McCausland, Shane Crotty Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J. Virol. Methods: 2008, 147(1);167-76 PMID:17920702
Maya F Kotturi, Bjoern Peters, Fernando Buendia-Laysa, John Sidney, Carla Oseroff, Jason Botten, Howard Grey, Michael J Buchmeier, Alessandro Sette The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J. Virol.: 2007, 81(10);4928-40 PMID:17329346
Leslie L Barton, Marilyn B Mets, Cynthia L Beauchamp Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am. J. Obstet. Gynecol.: 2002, 187(6);1715-6 PMID:12501090
L L Barton, M B Mets Congenital lymphocytic choriomeningitis virus infection: decade of rediscovery. Clin. Infect. Dis.: 2001, 33(3);370-4 PMID:11438904
L L Barton, C J Peters, T G Ksiazek Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen. Emerging Infect. Dis.: , 1(4);152-3 PMID:8903188 | PDF
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