Abnormal Development - Lymphocytic Choriomeningitis Virus
Lymphocytic choriomeningitis virus (LCMV) is carried by wild mice (Mus musculus). Laboratory rodents and pet rodents, such as rats, mice, hamsters and guinea pigs, can become infected with LCMV from contact with wild mice. This can happen in a breeding facility, in a laboratory facility, in a pet store, or in the home if wild mice are present. Humans can be infected through exposure to rodent excreta. In the rat animal model, the virus appears to selectively infect mitotically active neuronal precursors, while glial cells may also have a role in the initial entry, replication, and dispersion.
Maternal infection can be transferred placental to fetus and can result in either loss or birth defects (hydrocephalus, chorioretinitis or deafness). Since LCMV infection was first identified, more than 50 babies have been reported with LCMV infection worldwide.
- Viral Links: TORCH Infections | Cytomegalovirus | Hepatitis Virus | HIV | Measles Virus | Parvovirus | Polio Virus | Rubella Virus | Chickenpox | Lymphocytic Choriomeningitis Virus | Vaccination | Environmental
Some Recent Findings
Lineage: Viruses; ssRNA negative-strand viruses; Arenaviridae; Arenavirus; Old world arenaviruses; Lymphocytic choriomeningitis virus
- Lymphocytic choriomeningitis virus (strain Armstrong)
- Lymphocytic choriomeningitis virus (strain Pasteur)
- Lymphocytic choriomeningitis virus (strain Traub)
- Lymphocytic choriomeningitis virus (strain WE)
- Links: Genome
Diagnosis of congenital LCMV infection can be confirmed in infants by immunofluorescence antibody (IFA), enzyme-linked immunosorbent assays (ELISAs) or quantitative polymerase chain reaction (QPCR, or real time PCR (rtPCR)).
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Denise J Jamieson, Athena P Kourtis, Michael Bell, Sonja A Rasmussen Lymphocytic choriomeningitis virus: an emerging obstetric pathogen? Am. J. Obstet. Gynecol.: 2006, 194(6);1532-6 PMID:16731068
R Wright, D Johnson, M Neumann, T G Ksiazek, P Rollin, R V Keech, D J Bonthius, P Hitchon, C F Grose, W E Bell, J F Bale Congenital lymphocytic choriomeningitis virus syndrome: a disease that mimics congenital toxoplasmosis or Cytomegalovirus infection. Pediatrics: 1997, 100(1);E9 PMID:9200383
Megan M McCausland, Shane Crotty Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J. Virol. Methods: 2008, 147(1);167-76 PMID:17920702
Maya F Kotturi, Bjoern Peters, Fernando Buendia-Laysa, John Sidney, Carla Oseroff, Jason Botten, Howard Grey, Michael J Buchmeier, Alessandro Sette The CD8+ T-cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J. Virol.: 2007, 81(10);4928-40 PMID:17329346
Leslie L Barton, Marilyn B Mets, Cynthia L Beauchamp Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am. J. Obstet. Gynecol.: 2002, 187(6);1715-6 PMID:12501090
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Search Pubmed: Lymphocytic choriomeningitis virus
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Cite this page: Hill, M.A. (2014) Embryology Abnormal Development - Lymphocytic Choriomeningitis Virus. Retrieved August 23, 2014, from https://php.med.unsw.edu.au/embryology/index.php?title=Abnormal_Development_-_Lymphocytic_Choriomeningitis_Virus
- © Dr Mark Hill 2014, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G