File:Steroid hormone receptor family.gif

Overview of the steroid hormone receptor family

A. Phylogenetic tree of the Steroid Hormone Receptor (SHR) family showing the evolutionary interrelationships and distance between the various receptors. Based on alignments available at The NucleaRDB [Horn et al., 2001]. B. All steroid receptors are composed of a variable N-terminal domain (A/B) containing the AF-1 transactivation region, a highly conserved DNA Binding Domain (DBD), a flexible hinge region (D), and a C-terminal Ligand Binding Domain (LBD, E) containing the AF-2 transactivation region. The estrogen receptor α is unique in that it contains an additional C-terminal F domain. Numbers represent the length of the receptor in amino acids.

Figure 1: http://www.nursa.org/article.cfm?doi=10.1621/nrs.05003

Reference

Visualizing the action of steroid hormone receptors in living cells Alexander Griekspoor, Wilbert Zwart, Jacques Neefjes and Rob Michalides Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands Nuclear Receptor Signaling (2007) 5, e003. Article DOI: 10.1621/nrs.05003

Copyright © 2007, Griekspoor et al. This is an open-access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits unrestricted non-commercial use distribution and reproduction in any medium, provided the original work is properly cited.