File:Post-Golgi transport cartoon.jpg

Fig. 2 Fission of post-Golgi transport carriers.

a TGN precursors of post-Golgi carriers are pulled along microtubules by kinesin. The fission (red line) of the carriers occurs at the thinnest parts of the PGC precursor, which correspond to thin tubular segments of the TGN membrane at the electron microscopy level. In contrast, fission does not take place at the TGN regions with a complex morphology (i.e., containing tubular networks and fenestrae, or in thick vacuolar regions). If fission occurs close to the tip of a PGC precursor, the carrier will be smaller in size (1). In contrast, larger PGCs can be formed by cleavage at the bottom of a PGC precursor ( 2). b PGCs directed to endosomes detach from the TGN as simple clathrin-coated vesicles if fission (red line) occur at the neck of the clathrin-coated bud (1). Alternatively, entire chunks of the TGN membrane containing 2-3 clathrin-coated buds can be cleaved from the Golgi complex

Morphogenesis of post-Golgi transport carriers. Luini A, Mironov AA, Polishchuk EV, Polishchuk RS. Histochem Cell Biol. 2008 Feb;129(2):153-61. Epub 2008 Jan 23. Review. PMID: 18214517

Histochem Cell Biol. 2008 February; 129(2): 153–161. Published online 2008 January 23. doi: 10.1007/s00418-007-0365-8. Copyright © Springer-Verlag 2008