File:Golgi fragments during mitosis cartoon.jpg
Golgi fragmentation during mitosis
The mammalian Golgi apparatus (green) forms an interconnected ribbon adjacent to the centrosome (red) and the nucleus (blue). It nucleates a population of microtubules that is necessary for polarized protein transport. Plus (+) and minus ends (−) are indicated.
The activities of the protein kinases Plk3 and MEK1 and the fission protein BARS are required to convert the ribbon structure into isolated stacks in late G2 and prophase.
In metaphase, the isolated stacks are further fragmented by a Plk1- and Cdk1-dependent mechanism, producing vesicular/tubular membranes that are dispersed throughout the cytoplasm. During this process, ribbon determinants, which are proteins required for postmitotic Golgi ribbon formation, remain associated with the mitotic spindle for their partitioning into daughter cells. Centrosome-associated regulators of mitotic Golgi fragmentation are labeled in red. Regulators of Golgi fragmentation that are not associated with the centrosome are labeled in black.
Christine Sütterlin, Antonino Colanzi The Golgi and the centrosome: building a functional partnership. J. Cell Biol.: 2010, 188(5);621-8 PMID:20212314
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|current||20:50, 18 March 2012||1,001 × 262 (62 KB)||Z8600021||==Golgi fragmentation during mitosis== The mammalian Golgi apparatus (green) forms an interconnected ribbon adjacent to the centrosome (red) and the nucleus (blue). It nucleates a population of microtubules that is necessary for polarized protein transpo|
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